Mitf flybase

Author: bevp

August undefined, 2024

WebThe protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory ... Web21 jul. 2024 · Background The microphthalmia-associated transcription factor gene (MITF) belongs to the MYC supergene family and plays an important role in melanocytes’ homeostasis. Individuals harboring MITF germline pathogenic variants are at increased risk of developing cancer, most notably melanoma and renal cell carcinoma. Case …

30080 - Gene Resultmitfa melanocyte inducing transcription factor a ...

WebAlle advertenties van Flybase op Marktplaats. Bekijk het aanbod van Flybase en vind producten en diensten tegen aantrekkelijke prijzen! WebFlyBase Community Advisory Group; Recent Papers With Technical Advances; Gene Snapshots; FlyBase Forum; Newsletter; FlySlack Community; Twitter; NIH Funding; … ttc sherbourne station

MITF gene: MedlinePlus Genetics

Web3 sep. 2024 · MITF is crucial for melanocyte development and differentiation, and has been termed a lineage-specific oncogene in melanoma. The three related proteins MITF, … Web30 nov. 2014 · Introduction. Melanocytes are pigment-producing cells whose differentiation, proliferation and survival largely depend on MITF (microphthalmia-associated transcription factor), a melanocyte-specific transcription factor [for review 1, 2].Melanoma is a melanocyte-derived tumor in which MITF dependence is retained [for review 3]; thus, … Web21 feb. 2001 · Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and … phoenician store

$FlyBase Gene Report: Hsap\MITF$

Microphthalmia Associated Transcription Factor - an overview ...

Web1 apr. 2024 · pH-controlled histone acetylation amplifies melanocyte differentiation downstream of MITF. Mitf-family transcription factor function is required within cranial neural crest cells to promote choroid fissure closure. Melanosome maturation proteins Oca2, Mitfa and Vps11 are differentially required for cisplatin resistance in zebrafish melanocytes. Web15 feb. 2024 · FlyBase Wiki: Help Index; Tool help; Report help; FlyBase FAQ; Info for Authors. Author guidelines; Citing FlyBase; Fast-Track Your Paper Help; Gene … ttc shutdownWeb20 mei 2024 · The microphthalmia-associated transcription factor (MITF) is an important transcription factor that plays a key role in melanogenesis, cell proliferation, survival and immune defense in vertebrate. However, its function and function mechanism in bivalve are still rarely known. In this research, first, a Mitf gene was characterized from Pteria … ttc ship

"WebBertolotto et al. (2011) identified a missense mutation in MITF (E318K; 156845.0009) that greatly increases the risk of malignant melanoma and/or renal cell carcinoma in carriers, with an odds ratio of 14.46 (95% CI 3.74-48.04) for the risk of melanoma plus renal cell carcinoma. Yokoyama et al. (2011) independently identified the E318K mutation in the … " - Mitf flybase

Mitf flybase

The master role of microphthalmia-associated transcription

Web21 mrt. 2024 · MITF (Melanocyte Inducing Transcription Factor) is a Protein Coding gene. Diseases associated with MITF include Tietz Albinism-Deafness Syndrome and Melanoma, Cutaneous Malignant 8.Among its related pathways are Transport of the SLBP independent Mature mRNA and Metabolism of proteins.Gene Ontology (GO) annotations related to … Web15 feb. 2024 · FlyBase ID FBgn0086676 Gene Model Status Current Stock Availability 26 publicly available Gene Summary spinster ( spin) encodes a conserved transmembrane …

Did you know?

WebHoe erft de MITF E318K mutatie over? Zowel mannen als vrouwen kunnen drager zijn van de MITF E318K mutatie en deze doorgeven. Kinderen van een ouder met de MITF … WebFlyBase Community Advisory Group; Recent Papers With Technical Advances; Gene Snapshots; FlyBase Forum; Newsletter; FlySlack Community; Twitter; NIH Funding; …

Web30 nov. 2014 · Transcriptional repressors of MITF. Several transcription factors have been identified as direct repressors of MITF (Fig. 1).Inverse expression of GLI2 (glioma-associated oncogene family member 2) and MITF-M, relating to the mutually exclusive transcriptional programs, has been observed in melanoma cells [].GLI2 is a Kruppel-like … WebAchim A. Jungbluth, Klaus J. Busam, in Pathology of Melanocytic Tumors, 2024 MITF. Microphthalmia transcription factor (MITF) is a basic-loop-helix-loop leucine zipper (bHLH-Zip) transcription factor encoded by the MITF gene. 21 MITF is the human homologue of the mi gene in mice and can serve as an example how genetic research in mouse mutations …

WebAbstract. FlyBase is a database of genetic and molecular data concerning Drosophila. FlyBase is maintained as a relational database (in Sybase). The scope of FlyBase includes: genes, alleles (and phenotypes), aberrations, pointers to sequence data, clones, stock lists, Drosophila workers and bibliographic references. WebFlyBase 米英の大学のショウジョウバエの研究者などにより運営される、ショウジョウバエの生態や遺伝子情報に関するデータベース。 MGI 様々なプロジェクトによる、研究用マウスの遺伝的・生物学的なデータを提供するデータベース。

WebThe MITF gene provides instructions for making a protein called melanocyte inducing transcription factor. This protein plays a role in the development, survival, and function of …

WebAbstract. Microphthalmia-associated transcription factor (MITF) is a transcription factor with a basic-helix-loop-helix-leucine zipper (bHLHZip) structure. Mutations of the MITF gene cause a variety of phenotypes, most notably in pigmented cells, in several species. In humans, haploinsufficiency of MITF causes Waardenburg syndrome type 2, while ... ttc smash heusdenWebMicrophthalmia-associated transcription factor (MITF) is a transcription factor that regulates the expression of TYR, TRP-1, and TRP-2 [28] by binding to the M-box (5'-TCATGTG-3') and/or the E-box ... ttc shutdown scheduleWeb28 okt. 2024 · The MITF protein is a member of the MYC supergene family of basic-helix-loop-helix-leucine-zipper (bHLHZip) transcription factors and is known to regulate the expression of cell specific target... ttc snitch lineWeb2 okt. 2006 · MITF regulates the transcription of a variety of cell-specific genes, such as tyrosinase and pink-eyed Pmel 17 (silver) ( 14 ), c- kit ( 15 ), granzyme B ( 16) and tryptophan hydroxylase, and mast cell proteases, such as mouse mast cell protease 6 (mMCP6) ( 17 ). MITF is expressed in cardiomyocytes. ( A) Structure of MITF protein. phoenician surnamesWeb6 mrt. 2024 · MITF regulates expression of numerous pigmentation genes to promote melanocyte differentiation, as well as fundamental genes for maintaining cell … ttc sint-pauwelsWeb28 jan. 2024 · MITF belongs to the MiT family, gathering bHLH-LZ domain transcription factors (TFEB, TFEC and TFE3), that can homo- or hetero-dimerize to regulate gene … phoenicians summaryWeb13092-1-AP targets MITF in WB, IP, IF, FC, ELISA applications and shows reactivity with human, mouse, rat samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. phoenicians timeline