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Cyclic pifithrin-α hydrobromide

WebIt is 393 amino acids (aa) in length with a predicted molecular weight of 44 kDa. It belongs to the p53 family that also includes p63 and p73. Structurally, p53 is characterized by an N-terminal transactivation domain, central DNA-binding and oligomerization domains, and a C-terminal regulatory domain. WebCyclic Pifithrin-α (hydrobromide) from Cayman Chemical. Be the first to write a review! Citations: Description A stable analog of PFT-α, formed by the condensation of PFT-α in …

Cyclic Pifithrin-alpha Hydrobromide 511296-88-1 TCI AMERICA

WebCyclic Pifithrin-α hydrobromide. Synonym(s): 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide, Cyclic PFT-α hydrobromide, Pifithrin-α, cyclic, QB102. Empirical Formula (Hill Notation): C 16 H 16 N 2 S · HBr. CAS No.: 511296-88-1. Molecular Weight: 349.29. Compare Product No. Description SDS Pricing; P4236: WebPifithrin-α is firstly found to block the activation of p53-responsive lacZ in ConA cells and reduce activation of endogenous cellular p53-responsive genes. In MEF cells transformed with E1a+ras, 10μM Pifithrin-α can inhibit the apoptosis of the cells and this anti-apoptotic activity is p53-dependent. pottery barn 9 x 12 rugs https://instrumentalsafety.com

An evaluation of the ability of pifithrin-α and -β to inhibit p53 ...

WebCyclic Pifithrin-α hydrobromide CAS-No. 511296-88-1 Revision Date New Jersey Right To Know Components Cyclic Pifithrin-α hydrobromide CAS-No. 511296-88-1 Revision Date California Prop. 65 Components This product does not contain any chemicals known to the State of California to cause cancer, birth, or any other reproductive defects. WebPifithrin- α hydrobromide is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of … WebOur Cyclic Pifithrin-α hydrobromide is confirmed by NMR. Order now can get a discount! Cyclic Pifithrin-α hydrobromide(511296-88-1) Reference standards for … pottery barn 9x12 area rugs

Pifithrin-a hydrobromide Supplier CAS 63208-82-2 Tocris …

Category:Pifithrin-β hydrobromide (Synonyms: PFT β hydrobromide; Cyclic ...

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Cyclic pifithrin-α hydrobromide

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WebThis small molecule/inhibitor is primarily used for Activators/Inducers applications. Pricing and availability is not currently available. Properties Quality Level 100 form solid manufacturer/tradename Calbiochem® storage condition OK to freeze desiccated (hygroscopic) protect from light solubility DMSO: soluble (supplied) shipped in wet ice WebCyclic Pifithrin-α hydrobromide Synonym(s): 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide, Pifithrin-α, cyclic, Cyclic PFT-α hydrobromide, QB102 Empirical Formula (Hill Notation): C16H16N2S · HBr CAS No.: 511296-88-1 Molecular Weight: 349.29 Compare Product No. Description SDS Pricing P4236 ≥98% …

Cyclic pifithrin-α hydrobromide

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WebPifithrin-μ A cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Synonym (s): Pifithrin-μ, Phenylacetylenylsulfonamide, Hsp70 Inhibitor I Empirical Formula (Hill Notation): C8H7NO2S CAS Number: WebCyclic Pifithrin-α hydrobromide Synonym(s): 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide, Cyclic PFT-α hydrobromide, Pifithrin-α, cyclic, QB102 Empirical Formula (Hill Notation): C16H16N2S · HBr CAS No.: 511296-88-1 Molecular Weight: 349.29 Compare Product No. Description SDS Pricing P4236 ≥98% …

WebPifithrin-α is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. Pifithrin-α enhances … WebNational Center for Biotechnology Information

WebPifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC50 of 23 μM. For research use only. We do not sell to patients. Pifithrin-β hydrobromide …

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WebCyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α a small molecule inhibitor of p53. It reversibly inhibits p53-dependent transactivation of p53-responsive genes and … pottery barn 9 piece outdoor wood furnitureWebPifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist. For research use only. We do not sell to patients. Pifithrin-α hydrobromide Chemical Structure CAS No. : 63208-82-2 Get it tomorrow February 21 … pottery barn aaron armchairWebCyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine … pottery barn 9 trickWebPifithrin-α (10 μM) inhibits apoptotic death of C8 cells guided by etoposide, Taxol, Dox, cytosine arabinoside. Pifithrin-α has significant effect on the inhibition of p53-dependent … pottery barn aaron chairs craigslistWebCyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke−induced apoptosis of pulmonary endothelial cells. [ 1] Packaging 5, 10 mg in glass bottle Protect from light. Biochem/physiol Actions A stable analog of Pifithrin-α … touch the paper charm hangers genshinWebCyclic Pifthrin-Alpha is a cell-permeable and reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription. It is a more stable and less cytotoxic analog of the non-cyclic form of pifithrin-alpha. … pottery barn aaron barstoolWebSep 16, 2024 · Finally, we used pifithrin-α hydrobromide (PFT) as a p53 inhibitor to verify whether the high expression of p53 is involved in mediating this process. After PFT treatment, the live/dead cell rate, TFR, p53 expression, and GPX4 consumption were inhibited and mitigated the GSH/GSSG ratio reduction as well. pottery barn 9x12 wool rug